Mesotherapy is one of skin rejuvenation methods and known
to be effective for anti-aging, cosmetic treatment, and improvement
of obesity. Furthermore, the side effect of mesotherapy
has been known to be very little, therefore, it has been used
widely. Because of these reasons, complication of mesotherapy
has been disregarded. A 32-year-old woman visited a private
clinic for improvement of obesity. The patient had placenta injection
with aminophylline, lidocaine and epinephrine on abdomen
for several times and she did not have any symptoms. However,
placenta injection was carried out at the last time with aminophylline,
lidocaine, epinephrine and dehydrated alcohol. Four
days later, abdominal partial necrosis was developed. And she
was refered to our department. Wound of the abdomen had
eschar formation and reddish color change. So, debridement of
necrotic skin, and immediate reconstruction using flap and cosmetic
abdominoplasty were done immediately, and the patient
was satisfied with results. Based on various circumstances, we
concluded that one of the etiologies of necrosis might be
dehydrated alcohol and epinephrine effect. The standard of
materials that are mixed in mesotherapy has not yet been
established. In fact, the safety of additives has not yet been
verified. Therefore, more studies on the standard materials and
safety are needed.